Similar to Standard (Low Flux) hemodialysis except that the dialyzer being used is a high flux dialyzer.  High flux dialyzers  compared to low flux dialyzers have larger pores and allow diffusion of greater amounts  of uremic toxins including middle molecules such as B2 microglobulin which may reduce the risk of dialysis-related amyloidosis.

Specific indications for hi-flux dialysis are to reduce dialysis-related amyloidosis, to improve control of hyperphosphatemia, to reduce the increased cardiovascular risk, and to improve control of anemia.

High flux dialysis is performed three (3) times a week for four (4) hours using a high flux dialyzer which can be used one time (single use) or multiple times (reuse) by the same patient for up to eight (8) times. The dialysate flow in high flux dialysis is twice the blood flow rate (700-800 ml/min versus standard dialysis at 500 ml/min).