Hemodiafiltration is a type of renal replacement therapy that involves both the diffusive and convective clearance of uremic toxins.  In this type of dialysis, the ultrafiltration rate is much higher than that of the standard or high flux hemodialysis.  Since ultrafiltration rate is higher, a replacement fluid provided by the dialysis machine itself (online HDF) by further purifying the dialysis solution, is necessary. This type of dialysis can provide the largest removal of the widest range of molecular size of uremic toxins which include the middle- and the large-molecular weight toxins.

Similar to standard and high flux hemodialysis, hemodiafiltration is performed three (3) times a week for four (4) hours using a high flux dialyzer.